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    An, cetuximab, and radiation in locally advanced esophageal cancer. In two phase i studies, egfr-directed antibodies have shown activity in patients with esophageal cancer. In the phase i study of the humanized egfr mab emd72000, one patient with metastatic, pretreated squamous cell carcinoma had a durable, 6-month pr [61]. In addition, a phase i trial with abx-egf, a high-affinity, fully human igg2 egfr mab, reported stable disease for 7 months in one esophageal cancer patient [62]. Preclinical and these early clinical studies suggest potential activity and minimal toxicities with egfr antibodies for esophageal cancer. Tkis tkis are a class of oral, small molecules that inhibit atp binding within the tk domain, which completely inhibits egfr autophosphorylation and signal transduction [63]. Erlotinib (tarcevaâ®; osi pharmaceuticals, inc. , melville, ny, and gefinitib (iressaâ®; astrazeneca pharmaceuticals, wilmington, de, have been approved for second-line treatment in metastatic non-small cell lung cancer (nsclc). In several large, randomized trials for metastatic nsclc, both single-agent gefitinib and erlotinib showed significant objective response rates (9%–19%), disease control (36%–54%), and symptomatic improvement as second- or third-line treatment (35%–43%) [64–67]. buy cheap viagra cheap viagra online generic viagra online viagra for sale viagra for sale buy viagra online viagra without a doctor prescription viagra without a doctor prescription buy viagra online cheap viagra Only erlotinib as a single agent compared with placebo showed a survival advantage (6. 7 months versus 4. 7 months, p <. 001) [66]. No improvement in survival, however, was seen in platinum combination regimens with either erlotinib or gefitinib [68]. In those studies, higher response rates were correlated with skin rash, adenocarcinoma/bronchioalveolar carcinoma histology, female gender, japanese heritage, nonsmoking, and mutations in atp-binding site of the tk domain on egfr (exons 18–21) and kirstenras (k-ras) [69–73]. Given these promising results in nsclc, single-agent tkis have been studied, with varied outcomes, in several different pretreated cancer types, including head and neck squamous cell carcinoma (response rate [rr], 4%–11%), b. $24,00
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